Achieve Health – Retford, Nottinghamshire
A family history of depression or other mental health conditions can increase vulnerability. Genetic factors may influence how the brain regulates mood, stress, and emotional resilience.
Changes in brain chemistry—particularly involving neurotransmitters such as serotonin and dopamine—can affect mood regulation, motivation, and emotional stability, contributing to depressive symptoms.
Ongoing stress from work, financial pressure, caregiving responsibilities, or prolonged emotional strain can overwhelm the nervous system. Over time, this may disrupt hormonal balance and increase the risk of depression.
Experiences such as loss, grief, trauma, illness, or major life changes can trigger or worsen depression. These events may have lasting effects on emotional processing and stress responses.
Poor sleep quality, limited physical activity, nutritional imbalances, social isolation, and lack of routine can all contribute to low mood and reduced emotional wellbeing, making depression more difficult to manage.